diff --git a/config.def.h b/config.def.h
index 61d99392c6..4c88623291 100644
--- a/config.def.h
+++ b/config.def.h
@@ -353,6 +353,12 @@ static const bool def_history_list_enable = true;
 
 static const unsigned int def_user_language = 0;
 
+#if (defined(__APPLE__) && defined(__MACH__) && defined(OSX)) || (defined(_WIN32) && !defined(_XBOX))
+static const bool def_mouse_enable = true;
+#else
+static const bool def_mouse_enable = false;
+#endif
+
 /* VIDEO */
 
 #if defined(_XBOX360)
diff --git a/menu/menu_setting.c b/menu/menu_setting.c
index 47011565d0..ed3bbfc43a 100644
--- a/menu/menu_setting.c
+++ b/menu/menu_setting.c
@@ -5322,7 +5322,7 @@ static bool setting_append_list_menu_options(
          settings->menu.mouse.enable,
          menu_hash_to_str(MENU_LABEL_MOUSE_ENABLE),
          menu_hash_to_str(MENU_LABEL_VALUE_MOUSE_ENABLE),
-         false,
+         def_mouse_enable,
          menu_hash_to_str(MENU_VALUE_OFF),
          menu_hash_to_str(MENU_VALUE_ON),
          group_info.name,