diff --git a/devtools/client/inspector/markup/test/browser.ini b/devtools/client/inspector/markup/test/browser.ini
index 1100c28d60b1..df258bbb0b36 100644
--- a/devtools/client/inspector/markup/test/browser.ini
+++ b/devtools/client/inspector/markup/test/browser.ini
@@ -203,6 +203,7 @@ subsuite = clipboard
 [browser_markup_shadowdom_nested_pick_inspect.js]
 [browser_markup_shadowdom_noslot.js]
 [browser_markup_shadowdom_open_debugger.js]
+skip-if = (os == 'win' && processor == 'aarch64') # bug 1533507
 [browser_markup_shadowdom_shadowroot_mode.js]
 [browser_markup_shadowdom_show_nodes_button.js]
 [browser_markup_shadowdom_slotted_keyboard_focus.js]