diff --git a/dom/animation/KeyframeEffect.cpp b/dom/animation/KeyframeEffect.cpp
index 5e7a98e71017..abd6b6ae1d8c 100644
--- a/dom/animation/KeyframeEffect.cpp
+++ b/dom/animation/KeyframeEffect.cpp
@@ -1418,6 +1418,11 @@ KeyframeEffect::SetTarget(const Nullable<ElementOrCSSPseudoElement>& aTarget)
     ResetWinsInCascade();
 
     RequestRestyle(EffectCompositor::RestyleType::Layer);
+
+    nsAutoAnimationMutationBatch mb(mTarget->mElement->OwnerDoc());
+    if (mAnimation) {
+      nsNodeUtils::AnimationRemoved(mAnimation);
+    }
   }
 
   mTarget = newTarget;
@@ -1427,6 +1432,11 @@ KeyframeEffect::SetTarget(const Nullable<ElementOrCSSPseudoElement>& aTarget)
     MaybeUpdateProperties();
 
     RequestRestyle(EffectCompositor::RestyleType::Layer);
+
+    nsAutoAnimationMutationBatch mb(mTarget->mElement->OwnerDoc());
+    if (mAnimation) {
+      nsNodeUtils::AnimationAdded(mAnimation);
+    }
   }
 }