diff --git a/build/autoconf/sanitize.m4 b/build/autoconf/sanitize.m4
index 07dc86bc41e2..becdf0295d9d 100644
--- a/build/autoconf/sanitize.m4
+++ b/build/autoconf/sanitize.m4
@@ -40,7 +40,10 @@ if test -n "$MOZ_ASAN"; then
     if test -z "$CLANG_CL"; then
         LDFLAGS="-fsanitize=address -rdynamic $LDFLAGS"
     fi
+    AC_DEFINE(MOZ_ASAN)
+    MOZ_PATH_PROG(LLVM_SYMBOLIZER, llvm-symbolizer)
 fi
+AC_SUBST(MOZ_ASAN)
 
 dnl ========================================================
 dnl = Use Memory Sanitizer
@@ -51,7 +54,10 @@ if test -n "$MOZ_MSAN"; then
     if test -z "$CLANG_CL"; then
         LDFLAGS="-fsanitize=memory -fsanitize-memory-track-origins -rdynamic $LDFLAGS"
     fi
+    AC_DEFINE(MOZ_MSAN)
+    MOZ_PATH_PROG(LLVM_SYMBOLIZER, llvm-symbolizer)
 fi
+AC_SUBST(MOZ_MSAN)
 
 dnl ========================================================
 dnl = Use Thread Sanitizer
@@ -62,12 +68,16 @@ if test -n "$MOZ_TSAN"; then
     if test -z "$CLANG_CL"; then
         LDFLAGS="-fsanitize=thread -rdynamic $LDFLAGS"
     fi
+    AC_DEFINE(MOZ_TSAN)
+    MOZ_PATH_PROG(LLVM_SYMBOLIZER, llvm-symbolizer)
 fi
+AC_SUBST(MOZ_TSAN)
 
 dnl ========================================================
 dnl = Use UndefinedBehavior Sanitizer (with custom checks)
 dnl ========================================================
 if test -n "$MOZ_UBSAN_CHECKS"; then
+    MOZ_UBSAN=1
     UBSAN_TXT="$_objdir/ubsan_blacklist.txt"
     cat $_topsrcdir/build/sanitizers/ubsan_*_blacklist.txt > $UBSAN_TXT
     UBSAN_FLAGS="-fsanitize=$MOZ_UBSAN_CHECKS -fno-sanitize-recover=$MOZ_UBSAN_CHECKS -fsanitize-blacklist=$UBSAN_TXT"
@@ -76,12 +86,16 @@ if test -n "$MOZ_UBSAN_CHECKS"; then
     if test -z "$CLANG_CL"; then
         LDFLAGS="-fsanitize=undefined -rdynamic $LDFLAGS"
     fi
+    AC_DEFINE(MOZ_UBSAN)
+    MOZ_PATH_PROG(LLVM_SYMBOLIZER, llvm-symbolizer)
 fi
+AC_SUBST(MOZ_UBSAN)
 
 dnl ========================================================
 dnl = Use UndefinedBehavior Sanitizer to find integer overflows
 dnl ========================================================
 if test -n "$MOZ_SIGNED_OVERFLOW_SANITIZE$MOZ_UNSIGNED_OVERFLOW_SANITIZE"; then
+    MOZ_UBSAN=1
     SANITIZER_BLACKLISTS=""
     if test -n "$MOZ_SIGNED_OVERFLOW_SANITIZE"; then
         SANITIZER_BLACKLISTS="-fsanitize-blacklist=$_topsrcdir/build/sanitizers/ubsan_signed_overflow_blacklist.txt $SANITIZER_BLACKLISTS"
@@ -90,6 +104,7 @@ if test -n "$MOZ_SIGNED_OVERFLOW_SANITIZE$MOZ_UNSIGNED_OVERFLOW_SANITIZE"; then
         if test -z "$CLANG_CL"; then
             LDFLAGS="-fsanitize=signed-integer-overflow -rdynamic $LDFLAGS"
         fi
+        AC_DEFINE(MOZ_SIGNED_OVERFLOW_SANITIZE)
     fi
     if test -n "$MOZ_UNSIGNED_OVERFLOW_SANITIZE"; then
         SANITIZER_BLACKLISTS="-fsanitize-blacklist=$_topsrcdir/build/sanitizers/ubsan_unsigned_overflow_blacklist.txt $SANITIZER_BLACKLISTS"
@@ -98,10 +113,16 @@ if test -n "$MOZ_SIGNED_OVERFLOW_SANITIZE$MOZ_UNSIGNED_OVERFLOW_SANITIZE"; then
         if test -z "$CLANG_CL"; then
             LDFLAGS="-fsanitize=unsigned-integer-overflow -rdynamic $LDFLAGS"
         fi
+        AC_DEFINE(MOZ_UNSIGNED_OVERFLOW_SANITIZE)
     fi
     CFLAGS="$SANITIZER_BLACKLISTS $CFLAGS"
     CXXFLAGS="$SANITIZER_BLACKLISTS $CXXFLAGS"
+    AC_DEFINE(MOZ_UBSAN)
+    MOZ_PATH_PROG(LLVM_SYMBOLIZER, llvm-symbolizer)
 fi
+AC_SUBST(MOZ_SIGNED_OVERFLOW_SANITIZE)
+AC_SUBST(MOZ_UNSIGNED_OVERFLOW_SANITIZE)
+AC_SUBST(MOZ_UBSAN)
 
 dnl =======================================================
 dnl = Required for stand-alone (sanitizer-less) libFuzzer.
@@ -110,6 +131,9 @@ if test -n "$LIBFUZZER"; then
    LDFLAGS="$LIBFUZZER_FLAGS -rdynamic $LDFLAGS"
 fi
 
+# The LLVM symbolizer is used by all sanitizers
+AC_SUBST(LLVM_SYMBOLIZER)
+
 dnl ========================================================
 dnl = Test for whether the compiler is compatible with the
 dnl = given sanitize options.
diff --git a/build/moz.configure/toolchain.configure b/build/moz.configure/toolchain.configure
index c39a1bcfca97..9e9ae2657803 100644
--- a/build/moz.configure/toolchain.configure
+++ b/build/moz.configure/toolchain.configure
@@ -2429,8 +2429,6 @@ def asan():
 
 
 add_old_configure_assignment("MOZ_ASAN", asan)
-set_define("MOZ_ASAN", True, when=asan)
-set_config("MOZ_ASAN", True, when=asan)
 
 # MSAN
 # ==============================================================
@@ -2444,8 +2442,6 @@ def msan():
 
 
 add_old_configure_assignment("MOZ_MSAN", msan)
-set_define("MOZ_MSAN", True, when=msan)
-set_config("MOZ_MSAN", True, when=msan)
 
 # TSAN
 # ==============================================================
@@ -2459,8 +2455,6 @@ def tsan():
 
 
 add_old_configure_assignment("MOZ_TSAN", tsan)
-set_define("MOZ_TSAN", True, when=tsan)
-set_config("MOZ_TSAN", True, when=tsan)
 
 # UBSAN
 # ==============================================================
@@ -2497,6 +2491,7 @@ def ubsan(options, optimize):
 
 add_old_configure_assignment("MOZ_UBSAN_CHECKS", ubsan)
 
+
 option(
     "--enable-signed-overflow-sanitizer",
     help="Enable UndefinedBehavior Sanitizer (Signed Integer Overflow Parts)",
@@ -2509,8 +2504,6 @@ def ub_signed_overflow_san():
 
 
 add_old_configure_assignment("MOZ_SIGNED_OVERFLOW_SANITIZE", ub_signed_overflow_san)
-set_define("MOZ_SIGNED_OVERFLOW_SANITIZE", True, when=ub_signed_overflow_san)
-set_config("MOZ_SIGNED_OVERFLOW_SANITIZE", True, when=ub_signed_overflow_san)
 
 
 option(
@@ -2525,14 +2518,7 @@ def ub_unsigned_overflow_san():
 
 
 add_old_configure_assignment("MOZ_UNSIGNED_OVERFLOW_SANITIZE", ub_unsigned_overflow_san)
-set_define("MOZ_UNSIGNED_OVERFLOW_SANITIZE", True, when=ub_unsigned_overflow_san)
-set_config("MOZ_UNSIGNED_OVERFLOW_SANITIZE", True, when=ub_unsigned_overflow_san)
 
-#
-
-any_ubsan = ubsan | ub_signed_overflow_san | ub_unsigned_overflow_san
-set_define("MOZ_UBSAN", True, when=any_ubsan)
-set_config("MOZ_UBSAN", any_ubsan)
 
 # Security Hardening
 # ==============================================================
@@ -3136,16 +3122,6 @@ set_config("HAVE_LIBFUZZER_FLAG_FUZZER_NO_LINK", libfuzzer_flags.no_link_flag_su
 set_config("LIBFUZZER_FLAGS", libfuzzer_flags.use_flags)
 add_old_configure_assignment("LIBFUZZER_FLAGS", libfuzzer_flags.use_flags)
 
-# The LLVM symbolizer is used by all sanitizers
-check_prog(
-    "LLVM_SYMBOLIZER",
-    ("llvm-symbolizer",),
-    allow_missing=True,
-    paths=clang_search_path,
-    when=asan | msan | tsan | any_ubsan,
-)
-
-
 # Shared library building
 # ==============================================================
 
diff --git a/mobile/android/config/mozconfigs/android-x86_64/nightly-fuzzing-asan b/mobile/android/config/mozconfigs/android-x86_64/nightly-fuzzing-asan
index 6d00e50a0ba3..63467dafb210 100644
--- a/mobile/android/config/mozconfigs/android-x86_64/nightly-fuzzing-asan
+++ b/mobile/android/config/mozconfigs/android-x86_64/nightly-fuzzing-asan
@@ -15,9 +15,6 @@ ac_add_options --enable-fuzzing
 unset MOZ_STDCXX_COMPAT
 unset ENABLE_CLANG_PLUGIN
 
-# We don't have a native LLVM_SYMBOLIZER yet
-unset LLVM_SYMBOLIZER
-
 # Add the path to the clang_rt used, so it can be packaged with the build.
 if [ -d "$MOZ_FETCHES_DIR/clang" ]; then
     CLANG_LIB_DIR="$(cd $MOZ_FETCHES_DIR/clang/lib/clang/*/lib/linux && pwd)"