diff --git a/devtools/client/inspector/test/browser.ini b/devtools/client/inspector/test/browser.ini
index c6b7951d4c0e..7b94e5f49d09 100644
--- a/devtools/client/inspector/test/browser.ini
+++ b/devtools/client/inspector/test/browser.ini
@@ -152,7 +152,6 @@ skip-if = (e10s && debug) # Bug 1250058 - Docshell leak on debug e10s
 [browser_inspector_inspect-object-element.js]
 [browser_inspector_inspect_mutated_node.js]
 [browser_inspector_inspect_node_contextmenu.js]
-skip-if = fission # Nested same-process iframes are broken with Fission + contenttoolbox.fission. See Bug 1647366.
 [browser_inspector_invalidate.js]
 [browser_inspector_keyboard-shortcuts-copy-outerhtml.js]
 skip-if = (os == 'linux' && bits == 32 && debug) # bug 1328915, disable linux32 debug devtools for timeouts
diff --git a/testing/talos/talos/tests/devtools/addon/content/tests/inspector/custom.js b/testing/talos/talos/tests/devtools/addon/content/tests/inspector/custom.js
index caea5ce4e1fb..08de98f4408c 100644
--- a/testing/talos/talos/tests/devtools/addon/content/tests/inspector/custom.js
+++ b/testing/talos/talos/tests/devtools/addon/content/tests/inspector/custom.js
@@ -11,7 +11,6 @@ const {
 const {
   closeToolboxAndLog,
   garbageCollect,
-  isFissionEnabled,
   recordPendingPaints,
   runTest,
   testSetup,
@@ -26,14 +25,6 @@ const TEST_URL = PAGES_BASE_URL + "custom/inspector/index.html";
 module.exports = async function() {
   const tab = await testSetup(TEST_URL, { disableCache: true });
 
-  // Nested same-process iframes are broken with Fission +
-  // contenttoolbox.fission. See Bug 1647366.
-  // Bail out otherwise openToolboxWithInspectNode will throw.
-  if (isFissionEnabled()) {
-    await testTeardown();
-    return;
-  }
-
   const domReference = await getContentDOMReference("#initial-node", tab);
   let toolbox = await openToolboxWithInspectNode(domReference, tab);