diff --git a/modules/libpref/Preferences.cpp b/modules/libpref/Preferences.cpp
index b9a5ff4ce558..824e4783a45c 100644
--- a/modules/libpref/Preferences.cpp
+++ b/modules/libpref/Preferences.cpp
@@ -2896,6 +2896,8 @@ nsPrefBranch::DeleteBranch(const char* aStartingAt)
     nsDependentCString name(pref->Name());
     if (StringBeginsWith(name, branchName) || name.Equals(branchNameNoDot)) {
       iter.Remove();
+      // The saved callback pref may be invalid now.
+      gCallbackPref = nullptr;
     }
   }