diff --git a/devtools/client/accessibility/test/browser/browser.ini b/devtools/client/accessibility/test/browser/browser.ini
index e3ef86e8664d..52e6c4d7192c 100644
--- a/devtools/client/accessibility/test/browser/browser.ini
+++ b/devtools/client/accessibility/test/browser/browser.ini
@@ -15,6 +15,7 @@ support-files =
 skip-if = (os == 'win' && processor == 'aarch64') # bug 1533184
 [browser_accessibility_context_menu_inspector.js]
 skip-if = (os == 'win' && processor == 'aarch64') # bug 1533484
+[browser_accessibility_fission_switch_target.js]
 [browser_accessibility_mutations.js]
 skip-if = (os == 'win' && processor == 'aarch64') # bug 1533534
 [browser_accessibility_panel_highlighter.js]
diff --git a/devtools/client/accessibility/test/browser/browser_accessibility_fission_switch_target.js b/devtools/client/accessibility/test/browser/browser_accessibility_fission_switch_target.js
new file mode 100644
index 000000000000..75a27c7f76f7
--- /dev/null
+++ b/devtools/client/accessibility/test/browser/browser_accessibility_fission_switch_target.js
@@ -0,0 +1,50 @@
+/* Any copyright is dedicated to the Public Domain.
+ * http://creativecommons.org/publicdomain/zero/1.0/ */
+
+"use strict";
+
+// Test switching for the top-level target.
+
+const MAIN_PROCESS_URL = "about:robots";
+const MAIN_PROCESS_EXPECTED = [
+  {
+    expected: {
+      sidebar: {
+        name: "Gort! Klaatu barada nikto!",
+        role: "document",
+      },
+    },
+  },
+];
+
+const CONTENT_PROCESS_URL = buildURL(`<title>Test page</title>`);
+const CONTENT_PROCESS_EXPECTED = [
+  {
+    expected: {
+      sidebar: {
+        name: "Test page",
+        role: "document",
+      },
+    },
+  },
+];
+
+add_task(async () => {
+  await pushPref("devtools.target-switching.enabled", true);
+
+  info(
+    "Open a test page running on the content process and accessibility panel"
+  );
+  const env = await addTestTab(CONTENT_PROCESS_URL);
+  await runA11yPanelTests(CONTENT_PROCESS_EXPECTED, env);
+
+  info("Navigate to a page running on the main process");
+  await navigateTo(MAIN_PROCESS_URL);
+  await runA11yPanelTests(MAIN_PROCESS_EXPECTED, env);
+
+  info("Back to a page running on the content process");
+  await navigateTo(CONTENT_PROCESS_URL);
+  await runA11yPanelTests(CONTENT_PROCESS_EXPECTED, env);
+
+  await disableAccessibilityInspector(env);
+});