diff --git a/browser/extensions/formautofill/test/unit/xpcshell.ini b/browser/extensions/formautofill/test/unit/xpcshell.ini
index 6e031d6c2d09..710fdec3cf48 100644
--- a/browser/extensions/formautofill/test/unit/xpcshell.ini
+++ b/browser/extensions/formautofill/test/unit/xpcshell.ini
@@ -41,12 +41,18 @@ skip-if = (os == "linux") && ccov # bug 1614100
 [test_activeStatus.js]
 [test_addressDataLoader.js]
 [test_addressRecords.js]
+skip-if =
+  apple_silicon
 [test_autofillFormFields.js]
-skip-if = tsan # Times out, bug 1612707
+skip-if =
+  tsan # Times out, bug 1612707
+  apple_silicon
 [test_collectFormFields.js]
 [test_createRecords.js]
 [test_creditCardRecords.js]
-skip-if = tsan # Times out, bug 1612707
+skip-if =
+  tsan # Times out, bug 1612707
+  apple_silicon
 [test_extractLabelStrings.js]
 [test_findLabelElements.js]
 [test_getAdaptedProfiles.js]
@@ -54,7 +60,9 @@ skip-if = tsan # Times out, bug 1612707
 [test_getFormInputDetails.js]
 [test_getInfo.js]
 [test_getRecords.js]
-skip-if = tsan # Times out, bug 1612707
+skip-if =
+  tsan # Times out, bug 1612707
+  apple_silicon
 [test_isAvailable.js]
 [test_isCJKName.js]
 [test_isFieldEligibleForAutofill.js]
@@ -68,16 +76,24 @@ skip-if = tsan # Times out, bug 1612707
 [test_profileAutocompleteResult.js]
 [test_phoneNumber.js]
 [test_reconcile.js]
-skip-if = tsan # Times out, bug 1612707
+skip-if =
+  tsan # Times out, bug 1612707
+  apple_silicon
 [test_savedFieldNames.js]
 [test_toOneLineAddress.js]
 [test_storage_tombstones.js]
-skip-if = tsan # Times out, bug 1612707
+skip-if =
+  tsan # Times out, bug 1612707
+  apple_silicon
 [test_storage_remove.js]
-skip-if = tsan # Times out, bug 1612707
+skip-if =
+  tsan # Times out, bug 1612707
+  apple_silicon
 [test_storage_syncfields.js]
 [test_transformFields.js]
-skip-if = tsan # Times out, bug 1612707
+skip-if =
+  tsan # Times out, bug 1612707
+  apple_silicon
 [test_sync.js]
 head = head.js ../../../../../services/sync/tests/unit/head_appinfo.js ../../../../../services/common/tests/unit/head_helpers.js ../../../../../services/sync/tests/unit/head_helpers.js ../../../../../services/sync/tests/unit/head_http_server.js
 skip-if = tsan # Times out, bug 1612707
diff --git a/devtools/client/shared/remote-debugging/adb/xpcshell/xpcshell.ini b/devtools/client/shared/remote-debugging/adb/xpcshell/xpcshell.ini
index d2b34c105a59..4b8c74e2e193 100644
--- a/devtools/client/shared/remote-debugging/adb/xpcshell/xpcshell.ini
+++ b/devtools/client/shared/remote-debugging/adb/xpcshell/xpcshell.ini
@@ -8,4 +8,5 @@ support-files =
 
 [test_adb.js]
 run-sequentially = An extension having the same id is installed/uninstalled in different tests
+skip-if = apple_silicon
 [test_prepare-tcp-connection.js]
diff --git a/devtools/server/tests/xpcshell/xpcshell.ini b/devtools/server/tests/xpcshell/xpcshell.ini
index 566a502cee5c..c22469931c67 100644
--- a/devtools/server/tests/xpcshell/xpcshell.ini
+++ b/devtools/server/tests/xpcshell/xpcshell.ini
@@ -178,6 +178,7 @@ skip-if = true # breakpoint sliding is not supported bug 1525685
 [test_stepping-10.js]
 [test_stepping-11.js]
 [test_stepping-12.js]
+skip-if = apple_silicon
 [test_stepping-13.js]
 [test_stepping-14.js]
 [test_stepping-15.js]
@@ -207,6 +208,7 @@ skip-if = true # breakpoint sliding is not supported bug 1525685
 [test_watchpoint-02.js]
 [test_watchpoint-03.js]
 [test_watchpoint-04.js]
+skip-if = apple_silicon
 [test_watchpoint-05.js]
 [test_breakpoint-actor-map.js]
 skip-if = true # tests for breakpoint actors are obsolete bug 1524374
diff --git a/security/manager/ssl/tests/unit/xpcshell.ini b/security/manager/ssl/tests/unit/xpcshell.ini
index 9f4c581cdfd9..fbffc8e1ce27 100644
--- a/security/manager/ssl/tests/unit/xpcshell.ini
+++ b/security/manager/ssl/tests/unit/xpcshell.ini
@@ -178,6 +178,7 @@ run-sequentially = hardcoded ports
 [test_ocsp_url.js]
 run-sequentially = hardcoded ports
 [test_oskeystore.js]
+skip-if = apple_silicon
 [test_osreauthenticator.js]
 # Reauthentication has been implemented on Windows and MacOS, so running this
 # test results in the OS popping up a dialog, which means we can't run it in
diff --git a/toolkit/components/antitracking/test/xpcshell/xpcshell.ini b/toolkit/components/antitracking/test/xpcshell/xpcshell.ini
index 16a828a6745c..218988a8e400 100644
--- a/toolkit/components/antitracking/test/xpcshell/xpcshell.ini
+++ b/toolkit/components/antitracking/test/xpcshell/xpcshell.ini
@@ -11,6 +11,8 @@ skip-if = toolkit == "android" # Bug 1697936
 [test_staticPartition_font.js]
 support-files =
   data/font.woff
+skip-if =
+  apple_silicon
 [test_staticPartition_image.js]
 [test_staticPartition_authhttp.js]
 [test_staticPartition_prefetch.js]
diff --git a/toolkit/components/extensions/test/xpcshell/native_messaging.ini b/toolkit/components/extensions/test/xpcshell/native_messaging.ini
index b64cda83c8ba..d1551c3b3ecb 100644
--- a/toolkit/components/extensions/test/xpcshell/native_messaging.ini
+++ b/toolkit/components/extensions/test/xpcshell/native_messaging.ini
@@ -9,7 +9,9 @@ support-files =
 tags = webextensions
 
 [test_ext_native_messaging.js]
-skip-if = (os == "win" && processor == "aarch64") # bug 1530841
+skip-if =
+  (os == "win" && processor == "aarch64") # bug 1530841
+  apple_silicon
 [test_ext_native_messaging_perf.js]
 skip-if = tsan # Unreasonably slow, bug 1612707
 [test_ext_native_messaging_unresponsive.js]
diff --git a/toolkit/components/extensions/test/xpcshell/xpcshell-common-e10s.ini b/toolkit/components/extensions/test/xpcshell/xpcshell-common-e10s.ini
index 332921e68538..12e8dee6be69 100644
--- a/toolkit/components/extensions/test/xpcshell/xpcshell-common-e10s.ini
+++ b/toolkit/components/extensions/test/xpcshell/xpcshell-common-e10s.ini
@@ -3,11 +3,15 @@
 
 [test_ext_webRequest_filterResponseData.js]
 # tsan failure is for test_filter_301 timing out, bug 1674773
-skip-if = tsan || os == "android" && debug
+skip-if =
+  tsan || os == "android" && debug
+  apple_silicon
 [test_ext_webRequest_redirect_StreamFilter.js]
 [test_ext_webRequest_responseBody.js]
 skip-if = os == "android" && debug
 [test_ext_webRequest_startup_StreamFilter.js]
 skip-if = os == "android" && debug
 [test_ext_webRequest_viewsource_StreamFilter.js]
-skip-if = tsan # Bug 1683730
\ No newline at end of file
+skip-if =
+  tsan # Bug 1683730
+  apple_silicon
diff --git a/toolkit/components/extensions/test/xpcshell/xpcshell-common.ini b/toolkit/components/extensions/test/xpcshell/xpcshell-common.ini
index bb62bad173a4..70dae0901b29 100644
--- a/toolkit/components/extensions/test/xpcshell/xpcshell-common.ini
+++ b/toolkit/components/extensions/test/xpcshell/xpcshell-common.ini
@@ -44,7 +44,9 @@ run-sequentially = node server exceptions dont replay well
 skip-if = appname == "thunderbird" || os == "android" || (os == "mac" && debug) # CP service is disabled on Android, macosx1014/debug due to 1564534
 run-sequentially = node server exceptions dont replay well
 [test_ext_cookieBehaviors.js]
-skip-if = appname == "thunderbird" || tsan || os == "android" # Bug 1683730, Android: Bug 1700482
+skip-if =
+  appname == "thunderbird" || tsan || os == "android" # Bug 1683730, Android: Bug 1700482
+  apple_silicon
 [test_ext_cookies_firstParty.js]
 skip-if = appname == "thunderbird" || os == "android" || tsan # Android: Bug 1680132. tsan: Bug 1683730
 [test_ext_cookies_samesite.js]
@@ -55,9 +57,13 @@ skip-if = (os == "win" && debug) # Bug 1485567
 [test_ext_contentscript_async_loading.js]
 skip-if = os == 'android' && debug # The generated script takes too long to load on Android debug
 [test_ext_contentscript_context.js]
-skip-if = tsan # Bug 1683730
+skip-if =
+  tsan # Bug 1683730
+  apple_silicon
 [test_ext_contentscript_context_isolation.js]
-skip-if = tsan # Bug 1683730
+skip-if =
+  tsan # Bug 1683730
+  apple_silicon
 [test_ext_contentscript_create_iframe.js]
 [test_ext_contentscript_csp.js]
 [test_ext_contentscript_css.js]
diff --git a/toolkit/components/extensions/test/xpcshell/xpcshell-content.ini b/toolkit/components/extensions/test/xpcshell/xpcshell-content.ini
index 4d762d2c82b7..ee93e508c395 100644
--- a/toolkit/components/extensions/test/xpcshell/xpcshell-content.ini
+++ b/toolkit/components/extensions/test/xpcshell/xpcshell-content.ini
@@ -16,4 +16,5 @@ skip-if = !nightly_build
 [test_ext_shadowdom.js]
 skip-if = ccov && os == 'linux' # bug 1607581
 [test_ext_web_accessible_resources.js]
+skip-if = apple_silicon
 [test_ext_web_accessible_resources_matches.js]
diff --git a/toolkit/components/telemetry/tests/unit/xpcshell.ini b/toolkit/components/telemetry/tests/unit/xpcshell.ini
index 30ae469301e4..5efb160532af 100644
--- a/toolkit/components/telemetry/tests/unit/xpcshell.ini
+++ b/toolkit/components/telemetry/tests/unit/xpcshell.ini
@@ -28,6 +28,7 @@ generated-files =
 skip-if =
   debug || asan || tsan || os == "android" || release_or_beta
   apple_catalina # Bug 1713329
+  apple_silicon
 [test_client_id.js]
 [test_MigratePendingPings.js]
 [test_TelemetryHistograms.js]
diff --git a/toolkit/modules/subprocess/test/xpcshell/xpcshell.ini b/toolkit/modules/subprocess/test/xpcshell/xpcshell.ini
index 27eaa9fc7744..7b497eb01e3c 100644
--- a/toolkit/modules/subprocess/test/xpcshell/xpcshell.ini
+++ b/toolkit/modules/subprocess/test/xpcshell/xpcshell.ini
@@ -8,6 +8,8 @@ support-files =
   data_test_script.py
 
 [test_subprocess.js]
-skip-if = verify
+skip-if =
+  verify
+  apple_silicon
 [test_subprocess_getEnvironment.js]
 [test_subprocess_pathSearch.js]
diff --git a/toolkit/modules/tests/xpcshell/xpcshell.ini b/toolkit/modules/tests/xpcshell/xpcshell.ini
index debe905ddc7c..051e68236532 100644
--- a/toolkit/modules/tests/xpcshell/xpcshell.ini
+++ b/toolkit/modules/tests/xpcshell/xpcshell.ini
@@ -37,6 +37,7 @@ skip-if = toolkit == 'android'
 [test_ObjectUtils.js]
 [test_ObjectUtils_strict.js]
 [test_osKeyStore.js]
+skip-if = apple_silicon
 [test_PermissionsUtils.js]
 [test_Preferences.js]
 [test_Promise.js]