diff --git a/pcsx2/GS/Renderers/HW/GSRendererHW.cpp b/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
index e9acc6127d..0fa80144c1 100644
--- a/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
+++ b/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
@@ -3142,11 +3142,15 @@ void GSRendererHW::EmulateTextureSampler(const GSTextureCache::Source* tex)
 	const GSLocalMemory::psm_t& psm = GSLocalMemory::m_psm[tex->m_TEX0.PSM];
 	const GSLocalMemory::psm_t& cpsm = psm.pal > 0 ? GSLocalMemory::m_psm[m_context->TEX0.CPSM] : psm;
 
+	// Redundant clamp tests are restricted to local memory/1x sources only, if we're from a target,
+	// we keep the shader clamp. See #5851 on github, and the note in Draw().
 	[[maybe_unused]] static constexpr const char* clamp_modes[] = { "REPEAT", "CLAMP", "REGION_CLAMP", "REGION_REPEAT" };
-	const bool redundant_wms = IsRedundantClamp(m_context->CLAMP.WMS, m_context->CLAMP.MINU, m_context->CLAMP.MAXU, tex->m_TEX0.TW);
-	const bool redundant_wmt = IsRedundantClamp(m_context->CLAMP.WMT, m_context->CLAMP.MINV, m_context->CLAMP.MAXV, tex->m_TEX0.TH);
-	const u8 wms = EffectiveClamp(m_context->CLAMP.WMS, tex->m_region.HasX());
-	const u8 wmt = EffectiveClamp(m_context->CLAMP.WMT, tex->m_region.HasY());
+	const bool redundant_wms = !tex->m_target && IsRedundantClamp(m_context->CLAMP.WMS, m_context->CLAMP.MINU,
+													 m_context->CLAMP.MAXU, tex->m_TEX0.TW);
+	const bool redundant_wmt = !tex->m_target && IsRedundantClamp(m_context->CLAMP.WMT, m_context->CLAMP.MINV,
+													 m_context->CLAMP.MAXV, tex->m_TEX0.TH);
+	const u8 wms = EffectiveClamp(m_context->CLAMP.WMS, tex->m_region.HasX() || redundant_wms);
+	const u8 wmt = EffectiveClamp(m_context->CLAMP.WMT, tex->m_region.HasY() || redundant_wmt);
 	const bool complex_wms_wmt = !!((wms | wmt) & 2);
 	GL_CACHE("WMS: %s [%s%s] WMT: %s [%s%s] Complex: %d MINU: %d MINV: %d MINV: %d MAXV: %d",
 		clamp_modes[m_context->CLAMP.WMS], redundant_wms ? "redundant," : "", clamp_modes[wms],