diff --git a/pcsx2/GS/Renderers/Common/GSDevice.cpp b/pcsx2/GS/Renderers/Common/GSDevice.cpp
index 1b9e3ef7bd..878c346532 100644
--- a/pcsx2/GS/Renderers/Common/GSDevice.cpp
+++ b/pcsx2/GS/Renderers/Common/GSDevice.cpp
@@ -899,14 +899,13 @@ void GSDevice::ShadeBoost()
 	if (ResizeRenderTarget(&m_target_tmp, m_current->GetWidth(), m_current->GetHeight(), false, false))
 	{
 		// predivide to avoid the divide (multiply) in the shader
-		const float params[4] = {
+		const GSVector4 params(
 			static_cast<float>(GSConfig.ShadeBoost_Brightness) * (1.0f / 50.0f),
 			static_cast<float>(GSConfig.ShadeBoost_Contrast) * (1.0f / 50.0f),
 			static_cast<float>(GSConfig.ShadeBoost_Saturation) * (1.0f / 50.0f),
-			static_cast<float>(GSConfig.ShadeBoost_Gamma) * (1.0f / 50.0f),
-		};
+			static_cast<float>(GSConfig.ShadeBoost_Gamma) * (1.0f / 50.0f));
 
-		DoShadeBoost(m_current, m_target_tmp, params);
+		DoShadeBoost(m_current, m_target_tmp, params.v);
 
 		m_current = m_target_tmp;
 	}
diff --git a/pcsx2/GS/Renderers/DX11/GSDevice11.cpp b/pcsx2/GS/Renderers/DX11/GSDevice11.cpp
index ad8c61b3ef..9f511306bd 100644
--- a/pcsx2/GS/Renderers/DX11/GSDevice11.cpp
+++ b/pcsx2/GS/Renderers/DX11/GSDevice11.cpp
@@ -1397,7 +1397,7 @@ void GSDevice11::PresentRect(GSTexture* sTex, const GSVector4& sRect, GSTexture*
 	const float right = dRect.z * 2 / ds.x - 1.0f;
 	const float bottom = 1.0f - dRect.w * 2 / ds.y;
 
-	GSVertexPT1 vertices[] =
+	const GSVertexPT1 vertices[] =
 	{
 		{GSVector4(left, top, 0.5f, 1.0f), GSVector2(sRect.x, sRect.y)},
 		{GSVector4(right, top, 0.5f, 1.0f), GSVector2(sRect.z, sRect.y)},
@@ -1427,13 +1427,14 @@ void GSDevice11::PresentRect(GSTexture* sTex, const GSVector4& sRect, GSTexture*
 void GSDevice11::UpdateCLUTTexture(GSTexture* sTex, float sScale, u32 offsetX, u32 offsetY, GSTexture* dTex, u32 dOffset, u32 dSize)
 {
 	// match merge cb
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		float scale;
 		float pad1[3];
 		u32 offsetX, offsetY, dOffset;
+		u32 pad2;
 	};
-	const Uniforms cb = {sScale, {}, offsetX, offsetY, dOffset};
+	const Uniforms cb = {sScale, {}, offsetX, offsetY, dOffset, 0};
 	m_ctx->UpdateSubresource(m_merge.cb.get(), 0, nullptr, &cb, 0, 0);
 
 	const GSVector4 dRect(0, 0, dSize, 1);
@@ -1444,14 +1445,15 @@ void GSDevice11::UpdateCLUTTexture(GSTexture* sTex, float sScale, u32 offsetX, u
 void GSDevice11::ConvertToIndexedTexture(GSTexture* sTex, float sScale, u32 offsetX, u32 offsetY, u32 SBW, u32 SPSM, GSTexture* dTex, u32 DBW, u32 DPSM)
 {
 	// match merge cb
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		float scale;
 		float pad1[3];
 		u32 SBW, DBW, SPSM;
+		u32 pad2;
 	};
 
-	const Uniforms cb = {sScale, {}, SBW, DBW, SPSM};
+	const Uniforms cb = {sScale, {}, SBW, DBW, SPSM, 0};
 	m_ctx->UpdateSubresource(m_merge.cb.get(), 0, nullptr, &cb, 0, 0);
 
 	const GSVector4 dRect(0, 0, dTex->GetWidth(), dTex->GetHeight());
@@ -1461,7 +1463,7 @@ void GSDevice11::ConvertToIndexedTexture(GSTexture* sTex, float sScale, u32 offs
 
 void GSDevice11::FilteredDownsampleTexture(GSTexture* sTex, GSTexture* dTex, u32 downsample_factor, const GSVector2i& clamp_min, const GSVector4& dRect)
 {
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		float weight;
 		float step_multiplier;
@@ -2063,13 +2065,13 @@ void GSDevice11::RenderImGui()
 
 	UpdateImGuiTextures();
 
-	const float L = 0.0f;
+	constexpr float L = 0.0f;
 	const float R = static_cast<float>(m_window_info.surface_width);
-	const float T = 0.0f;
+	constexpr float T = 0.0f;
 	const float B = static_cast<float>(m_window_info.surface_height);
 
 	// clang-format off
-  const float ortho_projection[4][4] =
+	const GSVector4 ortho_projection[4] =
 	{
 		{ 2.0f/(R-L),   0.0f,           0.0f,       0.0f },
 		{ 0.0f,         2.0f/(T-B),     0.0f,       0.0f },
diff --git a/pcsx2/GS/Renderers/DX12/GSDevice12.cpp b/pcsx2/GS/Renderers/DX12/GSDevice12.cpp
index 40ec160bb5..c601ef0a27 100644
--- a/pcsx2/GS/Renderers/DX12/GSDevice12.cpp
+++ b/pcsx2/GS/Renderers/DX12/GSDevice12.cpp
@@ -1635,14 +1635,14 @@ void GSDevice12::UpdateCLUTTexture(
 	GSTexture* sTex, float sScale, u32 offsetX, u32 offsetY, GSTexture* dTex, u32 dOffset, u32 dSize)
 {
 	// match merge cb
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		float scale;
 		float pad1[3];
 		u32 offsetX, offsetY, dOffset;
 		u32 pad2;
 	};
-	const Uniforms cb = {sScale, {}, offsetX, offsetY, dOffset};
+	const Uniforms cb = {sScale, {}, offsetX, offsetY, dOffset, 0};
 	SetUtilityRootSignature();
 	SetUtilityPushConstants(&cb, sizeof(cb));
 
@@ -1656,14 +1656,15 @@ void GSDevice12::ConvertToIndexedTexture(
 	GSTexture* sTex, float sScale, u32 offsetX, u32 offsetY, u32 SBW, u32 SPSM, GSTexture* dTex, u32 DBW, u32 DPSM)
 {
 	// match merge cb
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		float scale;
 		float pad1[3];
 		u32 SBW, DBW, SPSM;
+		u32 pad2;
 	};
 
-	const Uniforms cb = {sScale, {}, SBW, DBW, SPSM};
+	const Uniforms cb = {sScale, {}, SBW, DBW, SPSM, 0};
 	SetUtilityRootSignature();
 	SetUtilityPushConstants(&cb, sizeof(cb));
 
@@ -1675,7 +1676,7 @@ void GSDevice12::ConvertToIndexedTexture(
 
 void GSDevice12::FilteredDownsampleTexture(GSTexture* sTex, GSTexture* dTex, u32 downsample_factor, const GSVector2i& clamp_min, const GSVector4& dRect)
 {
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		float weight;
 		float step_multiplier;
@@ -2184,7 +2185,7 @@ void GSDevice12::RenderImGui()
 	const float B = static_cast<float>(m_window_info.surface_height);
 
 	// clang-format off
-  const float ortho_projection[4][4] =
+	const GSVector4 ortho_projection[4] =
 	{
 		{ 2.0f/(R-L),   0.0f,           0.0f,       0.0f },
 		{ 0.0f,         2.0f/(T-B),     0.0f,       0.0f },
diff --git a/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp b/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp
index f1f8a415dc..39fb67072b 100644
--- a/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp
+++ b/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp
@@ -3131,7 +3131,7 @@ void GSDeviceVK::UpdateCLUTTexture(
 	GSTexture* sTex, float sScale, u32 offsetX, u32 offsetY, GSTexture* dTex, u32 dOffset, u32 dSize)
 {
 	// Super annoying, but apparently NVIDIA doesn't like floats/ints packed together in the same vec4?
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		u32 offsetX, offsetY, dOffset, pad1;
 		float scale;
@@ -3150,7 +3150,7 @@ void GSDeviceVK::UpdateCLUTTexture(
 void GSDeviceVK::ConvertToIndexedTexture(
 	GSTexture* sTex, float sScale, u32 offsetX, u32 offsetY, u32 SBW, u32 SPSM, GSTexture* dTex, u32 DBW, u32 DPSM)
 {
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		u32 SBW;
 		u32 DBW;
@@ -3171,7 +3171,7 @@ void GSDeviceVK::ConvertToIndexedTexture(
 
 void GSDeviceVK::FilteredDownsampleTexture(GSTexture* sTex, GSTexture* dTex, u32 downsample_factor, const GSVector2i& clamp_min, const GSVector4& dRect)
 {
-	struct Uniforms
+	struct alignas(16) Uniforms
 	{
 		GSVector2i clamp_min;
 		int downsample_factor;
@@ -4434,16 +4434,13 @@ void GSDeviceVK::RenderImGui()
 
 	UpdateImGuiTextures();
 
-	const float uniforms[2][2] = {{
-									  2.0f / static_cast<float>(m_window_info.surface_width),
-									  2.0f / static_cast<float>(m_window_info.surface_height),
-								  },
-		{
-			-1.0f,
-			-1.0f,
-		}};
+	const GSVector4 uniforms(
+		2.0f / static_cast<float>(m_window_info.surface_width),
+		2.0f / static_cast<float>(m_window_info.surface_height),
+		-1.0f,
+		-1.0f);
 
-	SetUtilityPushConstants(uniforms, sizeof(uniforms));
+	SetUtilityPushConstants(&uniforms, sizeof(uniforms));
 	SetPipeline(m_imgui_pipeline);
 
 	if (m_utility_sampler != m_linear_sampler)