diff --git a/libusb/os/darwin_usb.h b/libusb/os/darwin_usb.h
index 1180434..474567f 100644
--- a/libusb/os/darwin_usb.h
+++ b/libusb/os/darwin_usb.h
@@ -28,37 +28,58 @@
 #include <IOKit/IOCFPlugIn.h>
 
 /* IOUSBInterfaceInferface */
-#if defined (kIOUSBInterfaceInterfaceID700) && MAC_OS_X_VERSION_MIN_REQUIRED >= MAC_OS_X_VERSION_10_9
+
+/* New in OS 10.12.0. */
+#if defined (kIOUSBInterfaceInterfaceID800) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 101200)
+
+#define usb_interface_t IOUSBInterfaceInterface800
+#define InterfaceInterfaceID kIOUSBInterfaceInterfaceID800
+#define InterfaceVersion 800
+
+/* New in OS 10.10.0. */
+#elif defined (kIOUSBInterfaceInterfaceID700) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 101000)
 
 #define usb_interface_t IOUSBInterfaceInterface700
 #define InterfaceInterfaceID kIOUSBInterfaceInterfaceID700
 #define InterfaceVersion 700
 
-#elif defined (kIOUSBInterfaceInterfaceID550) && MAC_OS_X_VERSION_MIN_REQUIRED >= MAC_OS_X_VERSION_10_9
+/* New in OS 10.9.0. */
+#elif defined (kIOUSBInterfaceInterfaceID650) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1090)
+
+#define usb_interface_t IOUSBInterfaceInterface650
+#define InterfaceInterfaceID kIOUSBInterfaceInterfaceID650
+#define InterfaceVersion 650
+
+/* New in OS 10.8.2 but can't test deployment target to that granularity, so round up. */
+#elif defined (kIOUSBInterfaceInterfaceID550) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1090)
 
 #define usb_interface_t IOUSBInterfaceInterface550
 #define InterfaceInterfaceID kIOUSBInterfaceInterfaceID550
 #define InterfaceVersion 550
 
-#elif defined (kIOUSBInterfaceInterfaceID500)
+/* New in OS 10.7.3 but can't test deployment target to that granularity, so round up. */
+#elif defined (kIOUSBInterfaceInterfaceID500) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1080)
 
 #define usb_interface_t IOUSBInterfaceInterface500
 #define InterfaceInterfaceID kIOUSBInterfaceInterfaceID500
 #define InterfaceVersion 500
 
-#elif defined (kIOUSBInterfaceInterfaceID300)
+/* New in OS 10.5.0. */
+#elif defined (kIOUSBInterfaceInterfaceID300) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1050)
 
 #define usb_interface_t IOUSBInterfaceInterface300
 #define InterfaceInterfaceID kIOUSBInterfaceInterfaceID300
 #define InterfaceVersion 300
 
-#elif defined (kIOUSBInterfaceInterfaceID245)
+/* New in OS 10.4.5 (or 10.4.6?) but can't test deployment target to that granularity, so round up. */
+#elif defined (kIOUSBInterfaceInterfaceID245) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1050)
 
 #define usb_interface_t IOUSBInterfaceInterface245
 #define InterfaceInterfaceID kIOUSBInterfaceInterfaceID245
 #define InterfaceVersion 245
 
-#elif defined (kIOUSBInterfaceInterfaceID220)
+/* New in OS 10.4.0. */
+#elif defined (kIOUSBInterfaceInterfaceID220) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1040)
 
 #define usb_interface_t IOUSBInterfaceInterface220
 #define InterfaceInterfaceID kIOUSBInterfaceInterfaceID220
@@ -66,43 +87,57 @@
 
 #else
 
-#error "IOUSBFamily is too old. Please upgrade your OS"
+#error "IOUSBFamily is too old. Please upgrade your SDK and/or deployment target"
 
 #endif
 
 /* IOUSBDeviceInterface */
-#if defined (kIOUSBDeviceInterfaceID500) && MAC_OS_X_VERSION_MIN_REQUIRED >= MAC_OS_X_VERSION_10_9
+
+/* New in OS 10.9.0. */
+#if defined (kIOUSBDeviceInterfaceID650) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1090)
+
+#define usb_device_t    IOUSBDeviceInterface650
+#define DeviceInterfaceID kIOUSBDeviceInterfaceID650
+#define DeviceVersion 650
+
+/* New in OS 10.7.3 but can't test deployment target to that granularity, so round up. */
+#elif defined (kIOUSBDeviceInterfaceID500) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1080)
 
 #define usb_device_t    IOUSBDeviceInterface500
 #define DeviceInterfaceID kIOUSBDeviceInterfaceID500
 #define DeviceVersion 500
 
-#elif defined (kIOUSBDeviceInterfaceID320)
+/* New in OS 10.5.4 but can't test deployment target to that granularity, so round up. */
+#elif defined (kIOUSBDeviceInterfaceID320) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1060)
 
 #define usb_device_t    IOUSBDeviceInterface320
 #define DeviceInterfaceID kIOUSBDeviceInterfaceID320
 #define DeviceVersion 320
 
-#elif defined (kIOUSBDeviceInterfaceID300)
+/* New in OS 10.5.0. */
+#elif defined (kIOUSBDeviceInterfaceID300) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1050)
 
 #define usb_device_t    IOUSBDeviceInterface300
 #define DeviceInterfaceID kIOUSBDeviceInterfaceID300
 #define DeviceVersion 300
 
-#elif defined (kIOUSBDeviceInterfaceID245)
+/* New in OS 10.4.5 (or 10.4.6?) but can't test deployment target to that granularity, so round up. */
+#elif defined (kIOUSBDeviceInterfaceID245) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1050)
 
 #define usb_device_t    IOUSBDeviceInterface245
 #define DeviceInterfaceID kIOUSBDeviceInterfaceID245
 #define DeviceVersion 245
 
-#elif defined (kIOUSBDeviceInterfaceID220)
+/* New in OS 10.2.3 but can't test deployment target to that granularity, so round up. */
+#elif defined (kIOUSBDeviceInterfaceID197) && (MAC_OS_X_VERSION_MIN_REQUIRED >= 1030)
+
 #define usb_device_t    IOUSBDeviceInterface197
 #define DeviceInterfaceID kIOUSBDeviceInterfaceID197
 #define DeviceVersion 197
 
 #else
 
-#error "IOUSBFamily is too old. Please upgrade your OS"
+#error "IOUSBFamily is too old. Please upgrade your SDK and/or deployment target"
 
 #endif
 
diff --git a/libusb/version_nano.h b/libusb/version_nano.h
index 983f920..ae1c8d3 100644
--- a/libusb/version_nano.h
+++ b/libusb/version_nano.h
@@ -1 +1 @@
-#define LIBUSB_NANO 11279
+#define LIBUSB_NANO 11280