diff --git a/rpcs3/Emu/RSX/VK/VKDraw.cpp b/rpcs3/Emu/RSX/VK/VKDraw.cpp
index a63deca25f..d6bac9977f 100644
--- a/rpcs3/Emu/RSX/VK/VKDraw.cpp
+++ b/rpcs3/Emu/RSX/VK/VKDraw.cpp
@@ -147,7 +147,14 @@ VkRenderPass VKGSRender::get_render_pass()
 void VKGSRender::invalidate_render_pass()
 {
 	// Regenerate renderpass key for the next draw call
-	if (const auto key = vk::get_renderpass_key(m_fbo_images, m_current_renderpass_key);
+	std::vector<u8> input_attachments{};
+	if (current_fragment_program.ctrl & RSX_SHADER_CONTROL_PROGRAMMABLE_BLENDING)
+	{
+		input_attachments.resize(m_draw_buffers.size());
+		std::iota(input_attachments.begin(), input_attachments.end(), 0);
+	}
+
+	if (const auto key = vk::get_renderpass_key(m_fbo_images, m_current_renderpass_key, input_attachments);
 		key != m_current_renderpass_key)
 	{
 		m_current_renderpass_key = key;
diff --git a/rpcs3/Emu/RSX/VK/VKGSRender.cpp b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
index f701beac2f..1c3a22f957 100644
--- a/rpcs3/Emu/RSX/VK/VKGSRender.cpp
+++ b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
@@ -1804,6 +1804,12 @@ bool VKGSRender::load_program()
 
 		get_current_vertex_program(vs_sampler_state);
 
+		if (!!(current_fragment_program.ctrl & RSX_SHADER_CONTROL_PROGRAMMABLE_BLENDING) !=
+			vk::renderpass_has_input_attachments(m_current_renderpass_key))
+		{
+			invalidate_render_pass();
+		}
+
 		m_graphics_state.clear(rsx::pipeline_state::invalidate_pipeline_bits);
 	}
 	else if (!(m_graphics_state & rsx::pipeline_state::pipeline_config_dirty) &&
@@ -2665,7 +2671,15 @@ void VKGSRender::prepare_rtts(rsx::framebuffer_creation_context context)
 		}
 	}
 
-	m_current_renderpass_key = vk::get_renderpass_key(m_fbo_images);
+	std::vector<u8> input_attachments{};
+	if ((current_fragment_program.ctrl & RSX_SHADER_CONTROL_PROGRAMMABLE_BLENDING) &&
+		!m_graphics_state.test(rsx::pipeline_state::fragment_program_state_dirty))
+	{
+		input_attachments.resize(m_draw_buffers.size());
+		std::iota(input_attachments.begin(), input_attachments.end(), 0);
+	}
+
+	m_current_renderpass_key = vk::get_renderpass_key(m_fbo_images, input_attachments);
 	m_cached_renderpass = vk::get_renderpass(*m_device, m_current_renderpass_key);
 
 	// Search old framebuffers for this same configuration
@@ -2677,7 +2691,7 @@ void VKGSRender::prepare_rtts(rsx::framebuffer_creation_context context)
 		m_draw_fbo->release();
 	}
 
-	m_draw_fbo = vk::get_framebuffer(*m_device, fbo_width, fbo_height, VK_FALSE, m_cached_renderpass, m_fbo_images);
+	m_draw_fbo = vk::get_framebuffer(*m_device, fbo_width, fbo_height, vk::to_bool32(!input_attachments.empty()), m_cached_renderpass, m_fbo_images);
 	m_draw_fbo->add_ref();
 
 	set_viewport();
diff --git a/rpcs3/Emu/RSX/VK/VKRenderPass.cpp b/rpcs3/Emu/RSX/VK/VKRenderPass.cpp
index 9dc578ef66..b517054990 100644
--- a/rpcs3/Emu/RSX/VK/VKRenderPass.cpp
+++ b/rpcs3/Emu/RSX/VK/VKRenderPass.cpp
@@ -189,17 +189,23 @@ namespace vk
 		return key.encoded;
 	}
 
-	u64 get_renderpass_key(const std::vector<vk::image*>& images, u64 previous_key)
+	u64 get_renderpass_key(const std::vector<vk::image*>& images, u64 previous_key, const std::vector<u8>& input_attachment_ids)
 	{
 		// Partial update; assumes compatible renderpass keys
 		renderpass_key_blob key(previous_key);
 		key.layout_blob = 0;
+		key.input_attachments_mask = 0;
 
 		for (u32 i = 0; i < ::size32(images); ++i)
 		{
 			key.set_layout(i, images[i]->current_layout);
 		}
 
+		for (const auto& ref_id : input_attachment_ids)
+		{
+			key.set_input_attachment(ref_id);
+		}
+
 		return key.encoded;
 	}
 
@@ -348,6 +354,12 @@ namespace vk
 		return result;
 	}
 
+	bool renderpass_has_input_attachments(u64 renderpass_key)
+	{
+		renderpass_key_blob key(renderpass_key);
+		return key.input_attachments_mask != 0u;
+	}
+
 	void clear_renderpass_cache(VkDevice dev)
 	{
 		// Wipe current status
diff --git a/rpcs3/Emu/RSX/VK/VKRenderPass.h b/rpcs3/Emu/RSX/VK/VKRenderPass.h
index 5c23e749df..7b9494c934 100644
--- a/rpcs3/Emu/RSX/VK/VKRenderPass.h
+++ b/rpcs3/Emu/RSX/VK/VKRenderPass.h
@@ -9,11 +9,13 @@ namespace vk
 	class command_buffer;
 
 	u64 get_renderpass_key(const std::vector<vk::image*>& images, const std::vector<u8>& input_attachment_ids = {});
-	u64 get_renderpass_key(const std::vector<vk::image*>& images, u64 previous_key);
+	u64 get_renderpass_key(const std::vector<vk::image*>& images, u64 previous_key, const std::vector<u8>& input_attachment_ids = {});
 	u64 get_renderpass_key(VkFormat surface_format, u8 sample_count = 1);
 	u64 get_renderpass_key(VkFormat color_format, VkFormat depth_format, u8 sample_count = 1);
 	VkRenderPass get_renderpass(VkDevice dev, u64 renderpass_key);
 
+	bool renderpass_has_input_attachments(u64 renderpass_key);
+
 	void clear_renderpass_cache(VkDevice dev);
 
 	// Renderpass scope management helpers.
diff --git a/rpcs3/Emu/RSX/VK/VulkanAPI.h b/rpcs3/Emu/RSX/VK/VulkanAPI.h
index ad40634659..57e366c2a9 100644
--- a/rpcs3/Emu/RSX/VK/VulkanAPI.h
+++ b/rpcs3/Emu/RSX/VK/VulkanAPI.h
@@ -59,4 +59,6 @@ constexpr VkStructureType VK_STRUCTURE_TYPE_PHYSICAL_DEVICE_SHADER_UNIFORM_BUFFE
 namespace vk
 {
 	void init();
+
+	inline VkBool32 to_bool32(bool x) { return x ? VK_TRUE : VK_FALSE; }
 }