diff --git a/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp b/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp
index 9b07f8645e..f4caacfc6a 100644
--- a/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp
+++ b/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp
@@ -462,6 +462,12 @@ Texture2D* FramebufferManager::ResolveEFBColorTexture(const VkRect2D& region)
   // Can't resolve within a render pass.
   StateTracker::GetInstance()->EndRenderPass();
 
+  // It's not valid to resolve out-of-bounds coordinates.
+  // Ensuring the region is within the image is the caller's responsibility.
+  _assert_(region.offset.x >= 0 && region.offset.y >= 0 &&
+           (static_cast<u32>(region.offset.x) + region.extent.width) <= m_efb_width &&
+           (static_cast<u32>(region.offset.y) + region.extent.height) <= m_efb_height);
+
   // Resolving is considered to be a transfer operation.
   m_efb_color_texture->TransitionToLayout(g_command_buffer_mgr->GetCurrentCommandBuffer(),
                                           VK_IMAGE_LAYOUT_TRANSFER_SRC_OPTIMAL);
diff --git a/Source/Core/VideoBackends/Vulkan/Renderer.cpp b/Source/Core/VideoBackends/Vulkan/Renderer.cpp
index 9eafb0c22f..15fb00e77e 100644
--- a/Source/Core/VideoBackends/Vulkan/Renderer.cpp
+++ b/Source/Core/VideoBackends/Vulkan/Renderer.cpp
@@ -587,12 +587,11 @@ void Renderer::ResolveEFBForSwap(const TargetRectangle& scaled_rect)
 {
   // While the source rect can be out-of-range when drawing, the resolve rectangle must be within
   // the bounds of the texture.
-  TargetRectangle resolve_rect{scaled_rect};
-  resolve_rect.ClampUL(0, 0, m_target_width, m_target_height);
-
   VkRect2D region = {
-      {resolve_rect.left, resolve_rect.top},
-      {static_cast<u32>(resolve_rect.GetWidth()), static_cast<u32>(resolve_rect.GetHeight())}};
+      {scaled_rect.left, scaled_rect.top},
+      {static_cast<u32>(scaled_rect.GetWidth()), static_cast<u32>(scaled_rect.GetHeight())}};
+  region = Util::ClampRect2D(region, FramebufferManager::GetInstance()->GetEFBWidth(),
+                             FramebufferManager::GetInstance()->GetEFBHeight());
   FramebufferManager::GetInstance()->ResolveEFBColorTexture(region);
 }
 
diff --git a/Source/Core/VideoBackends/Vulkan/TextureCache.cpp b/Source/Core/VideoBackends/Vulkan/TextureCache.cpp
index 23cc06abff..08c370b48f 100644
--- a/Source/Core/VideoBackends/Vulkan/TextureCache.cpp
+++ b/Source/Core/VideoBackends/Vulkan/TextureCache.cpp
@@ -96,11 +96,14 @@ void TextureCache::CopyEFB(u8* dst, const EFBCopyFormat& format, u32 native_widt
   FramebufferManager::GetInstance()->FlushEFBPokes();
 
   // MSAA case where we need to resolve first.
-  // TODO: Do in one pass.
+  // An out-of-bounds source region is valid here, and fine for the draw (since it is converted
+  // to texture coordinates), but it's not valid to resolve an out-of-range rectangle.
   TargetRectangle scaled_src_rect = g_renderer->ConvertEFBRectangle(src_rect);
   VkRect2D region = {{scaled_src_rect.left, scaled_src_rect.top},
                      {static_cast<u32>(scaled_src_rect.GetWidth()),
                       static_cast<u32>(scaled_src_rect.GetHeight())}};
+  region = Util::ClampRect2D(region, FramebufferManager::GetInstance()->GetEFBWidth(),
+                             FramebufferManager::GetInstance()->GetEFBHeight());
   Texture2D* src_texture;
   if (is_depth_copy)
     src_texture = FramebufferManager::GetInstance()->ResolveEFBDepthTexture(region);
@@ -465,10 +468,14 @@ void TextureCache::TCacheEntry::FromRenderTarget(bool is_depth_copy, const EFBRe
   VkCommandBuffer command_buffer = g_command_buffer_mgr->GetCurrentCommandBuffer();
   StateTracker::GetInstance()->EndRenderPass();
 
-  // Transition EFB to shader resource before binding
+  // Transition EFB to shader resource before binding.
+  // An out-of-bounds source region is valid here, and fine for the draw (since it is converted
+  // to texture coordinates), but it's not valid to resolve an out-of-range rectangle.
   VkRect2D region = {{scaled_src_rect.left, scaled_src_rect.top},
                      {static_cast<u32>(scaled_src_rect.GetWidth()),
                       static_cast<u32>(scaled_src_rect.GetHeight())}};
+  region = Util::ClampRect2D(region, FramebufferManager::GetInstance()->GetEFBWidth(),
+                             FramebufferManager::GetInstance()->GetEFBHeight());
   Texture2D* src_texture;
   if (is_depth_copy)
     src_texture = FramebufferManager::GetInstance()->ResolveEFBDepthTexture(region);
diff --git a/Source/Core/VideoBackends/Vulkan/Util.cpp b/Source/Core/VideoBackends/Vulkan/Util.cpp
index 02ad129972..278a31aaee 100644
--- a/Source/Core/VideoBackends/Vulkan/Util.cpp
+++ b/Source/Core/VideoBackends/Vulkan/Util.cpp
@@ -97,6 +97,16 @@ u32 GetTexelSize(VkFormat format)
   }
 }
 
+VkRect2D ClampRect2D(const VkRect2D& rect, u32 width, u32 height)
+{
+  VkRect2D out;
+  out.offset.x = MathUtil::Clamp(rect.offset.x, 0, static_cast<int32_t>(width - 1));
+  out.offset.y = MathUtil::Clamp(rect.offset.y, 0, static_cast<int32_t>(height - 1));
+  out.extent.width = std::min(rect.extent.width, width - static_cast<uint32_t>(rect.offset.x));
+  out.extent.height = std::min(rect.extent.height, height - static_cast<uint32_t>(rect.offset.y));
+  return out;
+}
+
 VkBlendFactor GetAlphaBlendFactor(VkBlendFactor factor)
 {
   switch (factor)
diff --git a/Source/Core/VideoBackends/Vulkan/Util.h b/Source/Core/VideoBackends/Vulkan/Util.h
index f5385932bd..93e68efa9c 100644
--- a/Source/Core/VideoBackends/Vulkan/Util.h
+++ b/Source/Core/VideoBackends/Vulkan/Util.h
@@ -27,6 +27,9 @@ bool IsDepthFormat(VkFormat format);
 VkFormat GetLinearFormat(VkFormat format);
 u32 GetTexelSize(VkFormat format);
 
+// Clamps a VkRect2D to the specified dimensions.
+VkRect2D ClampRect2D(const VkRect2D& rect, u32 width, u32 height);
+
 // Map {SRC,DST}_COLOR to {SRC,DST}_ALPHA
 VkBlendFactor GetAlphaBlendFactor(VkBlendFactor factor);