diff --git a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp
index 54974aed7a..b84e8af571 100644
--- a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp
+++ b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp
@@ -64,9 +64,7 @@ void ControllerInterface::Initialize(const WindowSystemInfo& wsi)
 // nothing needed
 #endif
 #ifdef CIFACE_USE_OSX
-  if (m_wsi.type == WindowSystemType::MacOS)
-    ciface::OSX::Init(wsi.render_window);
-// nothing needed for Quartz
+// nothing needed for OSX and Quartz
 #endif
 #ifdef CIFACE_USE_SDL
   ciface::SDL::Init();
@@ -118,6 +116,18 @@ void ControllerInterface::RefreshDevices(RefreshReason reason)
   if (!m_is_init)
     return;
 
+#ifdef CIFACE_USE_OSX
+  if (m_wsi.type == WindowSystemType::MacOS)
+  {
+    std::lock_guard lk_pre_population(m_pre_population_mutex);
+    // This is needed to stop its threads before locking our mutexes, to avoid deadlocks
+    // (in case it tried to add a device after we had locked m_devices_population_mutex).
+    // There doesn't seem to be an easy to way to repopulate OSX devices without restarting
+    // its hotplug thread. This will not release its devices, that's still done below.
+    ciface::OSX::DeInit();
+  }
+#endif
+
   // This lock has two main functions:
   // -Avoid a deadlock between m_devices_mutex and ControllerEmu::s_state_mutex when
   // InvokeDevicesChangedCallbacks() is called concurrently by two different threads.
@@ -152,7 +162,10 @@ void ControllerInterface::RefreshDevices(RefreshReason reason)
 #ifdef CIFACE_USE_OSX
   if (m_wsi.type == WindowSystemType::MacOS)
   {
-    ciface::OSX::PopulateDevices(m_wsi.render_window);
+    {
+      std::lock_guard lk_pre_population(m_pre_population_mutex);
+      ciface::OSX::Init();
+    }
     ciface::Quartz::PopulateDevices(m_wsi.render_window);
   }
 #endif
diff --git a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h
index 826659941d..9c91d853e7 100644
--- a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h
+++ b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h
@@ -116,6 +116,7 @@ private:
 
   std::list<std::function<void()>> m_devices_changed_callbacks;
   mutable std::recursive_mutex m_devices_population_mutex;
+  mutable std::mutex m_pre_population_mutex;
   mutable std::mutex m_callbacks_mutex;
   std::atomic<bool> m_is_init;
   // This is now always protected by m_devices_population_mutex, so
diff --git a/Source/Core/InputCommon/ControllerInterface/OSX/OSX.h b/Source/Core/InputCommon/ControllerInterface/OSX/OSX.h
index 955b426f5e..f4ebc1a911 100644
--- a/Source/Core/InputCommon/ControllerInterface/OSX/OSX.h
+++ b/Source/Core/InputCommon/ControllerInterface/OSX/OSX.h
@@ -6,8 +6,7 @@
 
 namespace ciface::OSX
 {
-void Init(void* window);
-void PopulateDevices(void* window);
+void Init();
 void DeInit();
 
 void DeviceElementDebugPrint(const void*, void*);
diff --git a/Source/Core/InputCommon/ControllerInterface/OSX/OSX.mm b/Source/Core/InputCommon/ControllerInterface/OSX/OSX.mm
index 63bddf499e..8c80e9f529 100644
--- a/Source/Core/InputCommon/ControllerInterface/OSX/OSX.mm
+++ b/Source/Core/InputCommon/ControllerInterface/OSX/OSX.mm
@@ -135,8 +135,6 @@ static void DeviceDebugPrint(IOHIDDeviceRef device)
 #endif
 }
 
-static void* g_window;
-
 static std::string GetDeviceRefName(IOHIDDeviceRef inIOHIDDeviceRef)
 {
   const NSString* name = reinterpret_cast<const NSString*>(
@@ -172,10 +170,8 @@ static void DeviceMatchingCallback(void* inContext, IOReturn inResult, void* inS
   }
 }
 
-void Init(void* window)
+void Init()
 {
-  g_window = window;
-
   HIDManager = IOHIDManagerCreate(kCFAllocatorDefault, kIOHIDOptionsTypeNone);
   if (!HIDManager)
     ERROR_LOG_FMT(CONTROLLERINTERFACE, "Failed to create HID Manager reference");
@@ -210,19 +206,17 @@ void Init(void* window)
   });
 }
 
-void PopulateDevices(void* window)
-{
-  DeInit();
-  Init(window);
-}
-
 void DeInit()
 {
-  s_stopper.Signal();
-  s_hotplug_thread.join();
+  if (HIDManager)
+  {
+    s_stopper.Signal();
+    s_hotplug_thread.join();
 
-  // This closes all devices as well
-  IOHIDManagerClose(HIDManager, kIOHIDOptionsTypeNone);
-  CFRelease(HIDManager);
+    // This closes all devices as well
+    IOHIDManagerClose(HIDManager, kIOHIDOptionsTypeNone);
+    CFRelease(HIDManager);
+    HIDManager = nullptr;
+  }
 }
 }  // namespace ciface::OSX