diff --git a/Modules/FindPythonLibs.cmake b/Modules/FindPythonLibs.cmake
index cd623cf8f8..63ec9a84e2 100644
--- a/Modules/FindPythonLibs.cmake
+++ b/Modules/FindPythonLibs.cmake
@@ -168,12 +168,19 @@ foreach(_CURRENT_VERSION ${_Python_VERSIONS})
 
     # Use the library's install prefix as a hint
     set(_Python_INCLUDE_PATH_HINT)
-    get_filename_component(_Python_PREFIX ${PYTHON_LIBRARY} PATH)
-    get_filename_component(_Python_PREFIX ${_Python_PREFIX} PATH)
-    if(_Python_PREFIX)
-      set(_Python_INCLUDE_PATH_HINT ${_Python_PREFIX}/include)
-    endif()
-    unset(_Python_PREFIX)
+    # PYTHON_LIBRARY may contain a list because of SelectLibraryConfigurations
+    # which may have been run previously. If it is the case, the list can be:
+    #   optimized;<FILEPATH_TO_RELEASE_LIBRARY>;debug;<FILEPATH_TO_DEBUG_LIBRARY>
+    foreach(lib ${PYTHON_LIBRARY} ${PYTHON_DEBUG_LIBRARY})
+      if(IS_ABSOLUTE "${lib}")
+        get_filename_component(_Python_PREFIX "${lib}" PATH)
+        get_filename_component(_Python_PREFIX "${_Python_PREFIX}" PATH)
+        if(_Python_PREFIX)
+          list(APPEND _Python_INCLUDE_PATH_HINT ${_Python_PREFIX}/include)
+        endif()
+        unset(_Python_PREFIX)
+      endif()
+    endforeach()
 
     # Add framework directories to the search paths
     set(PYTHON_FRAMEWORK_INCLUDES)